Paynantheine, 500ug

SKU:
CAY-21841-500ug
  • $121.00

    • Description

    Paynantheine, 500ug

    Synonyms
    • (+)-Paynantheine
    Technical Information
    Formal Name
    (αE,2S,3R,12bS)-3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
    CAS Number
    4697-66-9
    Molecular Formula
    C23H28N2O4
    Formula Weight
    396.5
    Purity
    ≥98%
    A crystalline solid
    Solubility
    • DMF: 30 mg/ml
    • DMSO: 30 mg/ml
    • Ethanol: 30 mg/ml
    • Ethanol:PBS (pH7.2) (1:7): 0.125 mg/ml
    λmax
    226, 292 nm
    SMILES
    COC1=CC=CC2=C1C3=C([C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3)N2
    InChi Code
    InChI=1S/C23H28N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h5-8,13-14,16,19,24H,1,9-12H2,2-4H3/b17-13+/t14-,16-,19-/m0/s1
    InChi Key
    JGZKIGWXPPFMRG-CYSPOEIOSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Wet ice in continental US; may vary elsewhere
    Stability
    ≥ 2 years

    Paynantheine (Item No. 21841) is an alkaloid of the herbal drug M. speciosa (also known as kratom). Kratom (mitragynine; Item Nos. 11151 | 18567) has opioid-like and stimulant effects, and paynantheine can be detected in urine after kratom ingestion.1 Paynantheine blocks the delayed-rectifier potassium current in human induced pluripotent stem cell-derived cardiomyocytes (IC50 = 2.47 µM), suggesting that it may have cardiotoxic effects.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.