Paroxetine-d6 (hydrochloride), 1MG

SKU:
CAY-35603-1MG
  • $268.00

    • Description

    Paroxetine-d6 (hydrochloride)

    Product Description

    Paroxetine-d6 is intended for use as an internal standard for the quantification of paroxetine (Item No. 14998) by GC- or LC-MS. Paroxetine is a selective serotonin reuptake inhibitor (SSRI; Ki = 0.04 nM).1 It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (Kis = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A, the histamine H1 receptor, α1- and α2-adrenergic receptors (α2-ARs), and muscarinic acetylcholine receptors (mAChRs; Kis = 21,168, 6,320, 13,746, 995, 3,915, and 42 nM, respectively).1,2 Paroxetine (5 mg/kg) decreases immobility time in the forced swim test in mice.3 Formulations containing paroxetine have been used in the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, social and generalized anxiety disorders, and post-traumatic stress disorder (PTSD).

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl-d2]-4-(4-fluorophenyl)-piperidine-2,2,6,6-d4, monohydrochloride
    Molecular Formula
    C19H14D6FNO3 • HCl
    Formula Weight
    371.9
    Purity
    ≥99% deuterated forms (d1-d6)
    Formulation(Request formulation change)
    A solid
    Solubility(Learn about Variance in Solubility)
    • DMF: 33 mg/ml
    • DMSO: 20 mg/ml
    • Ethanol: 20 mg/ml
    SMILES
    FC1=CC=C([C@H]2[C@H](C([2H])([2H])OC3=CC(OCO4)=C4C=C3)C([2H])([2H])NC([2H])([2H])C2)C=C1.Cl
    InChi Code
    InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1/i8D2,10D2,11D2;
    InChi Key
    GELRVIPPMNMYGS-UGESGLEFSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years