Paliperidone-d₄

Paliperidone-d₄ is intended for use as an internal standard for the quantification of paliperidone (Item No. 15556) by GC- or LC-MS. Paliperidone is an atypical antipsychotic.¹ It is an inverse agonist of dopamine D₂ and D₃ receptors (IC₅₀s = 1 and 0.9 nM, respectively), as well as an antagonist at these receptors (K_is = 0.4 and 0.1 nM, respectively).² Paliperidone also binds to α₁- and α₂-adrenergic receptors, histamine H₁ receptors, and the serotonin (5-HT) receptor subtypes 5-HT_1A, 5-HT_1D, 5-HT_2A, and 5-HT_2C (K_ds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively).³ It improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia when administered at a dose of 0.05 mg/kg per day.¹ Paliperidone is also an active metabolite of the atypical antipsychotic risperidone (Item No. 13629).³ Formulations containing paliperidone have been used in the treatment of schizophrenia and schizoaffective disorder.

WARNING This product is not for human or veterinary use.