Paliperidone-d4, 500UG

SKU:
CAY-28484-500UG
  • $158.00

    • Description

    Paliperidone-d4

    Paliperidone-d4 is intended for use as an internal standard for the quantification of paliperidone (Item No. 15556) by GC- or LC-MS. Paliperidone is an atypical antipsychotic.1 It is an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively), as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively).2 Paliperidone also binds to α1- and α2-adrenergic receptors, histamine H1 receptors, and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively).3 It improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia when administered at a dose of 0.05 mg/kg per day.1 Paliperidone is also an active metabolite of the atypical antipsychotic risperidone (Item No. 13629).3 Formulations containing paliperidone have been used in the treatment of schizophrenia and schizoaffective disorder.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-1,1,2,2-d4]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
    CAS Number
    1020719-55-4
    Synonyms
    • 9-hydroxy Risperidone-d4
    Molecular Formula
    C23H23D4FN4O3
    Formula Weight
    430.5
    Purity
    ≥99% deuterated forms (d1-d4)
    Formulation(Request formulation change)
    A solid
    Solubility
    • Chloroform: slightly soluble
    • DMSO: slightly soluble
    • Methanol: slightly soluble
    SMILES
    OC1C(N2CCC1)=NC(C)=C(C([2H])([2H])C([2H])([2H])N3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)C2=O
    InChi Code
    InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3/i8D2,12D2
    InChi Key
    PMXMIIMHBWHSKN-FJVJJXCISA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years