p-Toluenesulfonyl chloride ReagentPlus, 100g

SKU:
240877-100G
  • p-Toluenesulfonyl chloride ReagentPlus, 100g
  • p-Toluenesulfonyl chloride ReagentPlus, 100g
  • $136.00

    • Description

    p-Toluenesulfonyl chloride ReagentPlus, ≥99%

    Synonym(s):
    TsCl, Tosyl chloride
    Linear Formula:
    CH3C6H4SO2Cl
    CAS Number:
    98-59-9
    Molecular Weight:
    190.65
    Beilstein:
    607898
    EC Number:
    202-684-8
    MDL number:
    MFCD00007450
    PubChem Substance ID:
    57648053
    NACRES:
    NA.21

    vapor pressure

    1 mmHg ( 88 °C)

    Quality Level

    200

    product line

    ReagentPlus®

    assay

    ≥99%

    bp

    134 °C/10 mmHg (lit.)

    mp

    65-69 °C (lit.)

    solubility

    benzene: freely soluble(lit.)
    chloroform: freely soluble(lit.)
    ethanol: freely soluble(lit.)
    water: insoluble(lit.)

    SMILES string

    Cc1ccc(cc1)S(Cl)(=O)=O

    InChI

    1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3

    InChI key

    YYROPELSRYBVMQ-UHFFFAOYSA-N

    General description

    p-Toluenesulfonyl chloride is an organic sulfonyl chloride mainly used to convert hydroxyl groups into good leaving group by forming sulfonates.

    Application

    p-Toluenesulfonyl chloride may be used in the following processes:
    • In combination with N-methylimidazole for the esterification or thioesterification of carboxylic acids and alcohols or thiols.
    • As an additive to enhance the yield of symmetrical biaryls via palladium chloride catalyzed homo-coupling of arylboronic acids in the absence of ligands.
    • As a positive chlorine source for the ?-chlorination of ketones.
    • Solvent-free tosylation of alcohols and phenols in the presence of heterodoxy acids.
    • As an activator for reaction between 2-alkynylbenzaldoxime and phenols to form 1-aroxyisoquinolines in the presence of silver triflate.
    • As a catalyst for the solvent-free preparation of symmetrical bis(benzhydryl)ethers from benzhydrols.

    Packaging

    5 g in glass bottle
    100, 500 g in poly bottle

    Legal Information

    ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

    SAFETY INFORMATION

    Pictograms

    GHS05,GHS07

    Signal Word

    Danger

    Hazard Statements

    H290 - H315 - H317 - H318

    Precautionary Statements

    P280 - P302 + P352 - P305 + P351 + P338 + P310

    Hazard Classifications

    Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1

    Storage Class Code

    8B - Non-combustible, corrosive hazardous materials

    WGK

    WGK 1

    Flash Point(F)

    262.4 °F

    Flash Point(C)

    128 °C

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves