Orientin, 25MG

SKU:
CAY-25143-25MG
  • $61.00

    • Description

    Orientin, 25MG

    Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties.1,2,3,4 Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 316.21 µg/ml.2 It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 µg/ml and a cytotoxic concentration (CC50) value of 375 µg/ml in Hep-2 cells.3 Orientin (5-40 µM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs).4 It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 µg/animal 12 hours after LPS administration.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
    CAS Number
    28608-75-5
    Molecular Formula
    C21H20O11
    Formula Weight
    448.4
    Purity
    ≥95%
    Formulation(Request formulation change)
    A crystalline solid
    λmax
    258, 351 nm
    SMILES
    OC1=CC(O)=C(C(C=C(C2=CC=C(O)C(O)=C2)O3)=O)C3=C1[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4
    InChi Code
    InChI=1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1
    InChi Key
    PLAPMLGJVGLZOV-VPRICQMDSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years