Olanzapine-d8, 1MG

SKU:
CAY-25447-1MG
  • $309.00

    • Description

    Olanzapine-d8

    Product Description

    Olanzapine-d8 is intended for use as an internal standard for the quantification of olanzapine (Item No. 11937) by GC- or LC-MS. Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).1 It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.2 It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.3 Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.

    WARNING This product is not for human or veterinary use.

    echnical Information
    Formal Name
    2-methyl-4-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)-10H-thieno[2,3-b][1,5]benzodiazepine
    CAS Number
    1093380-13-2
    Molecular Formula
    C17H12D8N4S
    Formula Weight
    320.5
    Purity
    ≥99% deuterated forms (d1-d8)
    A solid
    • DMF: 20 mg/ml
    • DMSO: 15 mg/ml
    • Ethanol: 1 mg/ml
    SMILES
    CN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1C2=NC3=CC=CC=C3NC4=C2C=C(C)S4
    InChi Code
    InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3/i7D2,8D2,9D2,10D2
    InChi Key
    KVWDHTXUZHCGIO-UFBJYANTSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years