Description
(±)-O-Des
(±)-O-Desmethyl venlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.1 It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.2 Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.1 It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces immobility time in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.3 It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.
WARNING This product is not for human or veterinary use.
Technical Information
- Desvenlafaxine
- DVS 233
- MDD-XR
- DMF: 5 mg/ml
- DMF:PBS (pH 7.2) (1:2): 0.30 mg/ml
- DMSO: 0.25 mg/ml
- Ethanol: 0.10 mg/ml
Shipping & Storage Information
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Cayman Chemical Co.O-Desmethyl Venlafaxine (CRM)
SKU: CAY-40325-100Ug
$100.00(±)-O-Desmethyl Venlafaxine (CRM) (±)-O-Desmethyl venlafaxine (CRM) (Item No. 40325) is a certified reference material categorized as an antidepressant.1 (±)-O-Desmethyl venlafaxine is an active... -
Cayman Chemical Co.O-Desmethyl Venlafaxine-d6, 1MG
SKU: CAY-15843-1MG
$182.00(±)-O-Desmethyl Venlafaxine-d6 Product Description (±)-O-Desmethyl venlafaxine-d6 (Item No. 15843) is an analytical reference standard intended for use as an internal standard for the... -
LGCCarbodenafil-desmethyl, 10MG
SKU: DRE-C11002100
$517.00Carbodenafil-desmethyl, 10MG Synonyms: Desmethylcarbodenafil, 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one,... -
LGCO-Desmethylvenlafaxine 0.1 mg/ml in Methanol
SKU: LGCAMP0393.01-02
$100.00O-Desmethylvenlafaxine 0.1 mg/ml in Methanol -
Lipomed, IncO-Desmethylvenlafaxine-D6, 1.0 mg/1 ml calibrated in methanol
SKU: VLF-1878-FB-1LM
$575.64O-Desmethylvenlafaxine-D6, 1.0 mg/1 ml calibrated in methanol Product reference number VLF-1878-FB Full chemical name d,l-4-[2-Ditrideuteromethylamino-1-(1-hydroxycyclohe -
MilliporeSigmaO-Desmethylvenlafaxine solution 1.0 mg/mL in methanol, certified reference material, Cerilliant
SKU: V-045-1ML
$428.00O-Desmethylvenlafaxine solution 1.0 mg/mL in methanol, certified reference material, Cerilliant Empirical Formula (Hill Notation): C16H25NO2 CAS Number: 93413-62-8 Molecular... -
Cayman Chemical Co.O-Desmethyl-cis-tramadol (hydrochloride) (CRM), 1MG
SKU: CAY-18751-1MG
$81.00O-Desmethyl-cis-tramadol (hydrochloride) (CRM) O-Desmethyl-cis-tramadol (hydrochloride) (CRM) (Item No. 18751) is a certified reference material that is structurally categorized as an opioid. It is... -
Cayman Chemical Co.O-Desmethyl-cis-tramadol-d6 (hydrochloride) (CRM)
SKU: CAY-20593-1MG
$601.00O-Desmethyl-cis-tramadol-d6 (hydrochloride) (CRM) (Item No. 20593) is intended for use as an internal standard for the quantification of O-desmethyl-cis-tramadol (Item Nos. 18751 | 13976) by GC- or... -
MilliporeSigmaO-Desmethylvenlafaxine solution 100 ug/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant
SKU: V-007-1ML
$95.50O-Desmethylvenlafaxine solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant Empirical Formula (Hill Notation): C16H25NO2 CAS Number:...
