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Nicotine, 500G

SKU:
N0267-500MG
  • $411.00

    • Description

    (±)-Nicotine, ≥99% (TLC), liquid, 500MG

    Empirical Formula (Hill Notation):
    C10H14N2
    CAS Number:
    22083-74-5
    Molecular Weight:
    162.23
    Beilstein:
    82108
    MDL number:
    MFCD00065370
    eCl@ss:
    39151701
    PubChem Substance ID:
    24897418

    Quality Level

    200

    assay

    ≥99% (TLC)

    form

    liquid

    optical activity

    [α]25/D 0°(lit.)

    color

    yellow

    solubility

    ethanol: 50 mg/mL

    density

    1.02 g/mL at 25 °C (lit.)

    SMILES string

    CN1CCCC1c2cccnc2

    InChI

    1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3

    InChI key

    SNICXCGAKADSCV-UHFFFAOYSA-N

    Gene Information

    human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137)
    rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

    (±)-Nicotine has been used:
    • as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
    • as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
    • as a test compound to study its effects on fibril formation

    Packaging

    100, 500 mg in ampule
    1 g in ampule

    Biochem/physiol Actions

    Prototype nicotinic acetylcholine receptor agonist.
    (±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

    Pictograms

    GHS06,GHS09

    Signal Word

    Danger

    Hazard Statements

    H301 - H310 - H411

    Precautionary Statements

    P262 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P310

    Hazard Classifications

    Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2

    Storage Class Code

    6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

    WGK

    WGK 3

    Flash Point(F)

    213.8 °F - closed cup

    Flash Point(C)

    101 °C - closed cup

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves