N,N-Dimethylformamide anhydrous, 1L

SKU:
227056-1L
  • $134.00

    • Description

    N,N-Dimethylformamide anhydrous, 99.8%, 1L

    Synonym(s):
    DMF, NSC 5356
    Linear Formula:
    HCON(CH3)2
    CAS Number:
    68-12-2
    Molecular Weight:
    73.09
    Beilstein:
    605365
    EC Number:
    200-679-5
    MDL number:
    MFCD00003284
    PubChem Substance ID:
    57647999
    NACRES:
    NA.21

    Quality Level

    300

    grade

    anhydrous

    vapor density

    2.5 (vs air)

    vapor pressure

    2.7 mmHg ( 20 °C)

    assay

    99.8%

    form

    liquid

    autoignition temp.

    833 °F

    expl. lim.

    15.2 %

    impurities

    <0.005% water

    evapn. residue

    <0.0005%

    refractive index

    n20/D 1.430 (lit.)

    pH

    7 (20 °C, 200 g/L)

    bp

    153 °C (lit.)

    mp

    −61 °C (lit.)

    density

    0.944 g/mL (lit.)

    SMILES string

    [H]C(=O)N(C)C

    InChI

    1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

    InChI key

    ZMXDDKWLCZADIW-UHFFFAOYSA-N

    N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups.
    N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.

    Application

    N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It may be employed as solvent medium for the various organic reduction reactions.
    DMF has been used as a solvent in the following processes:
    • Multi-step synthesis of L-azidohomoalanine (L-Aha) during the substitution of the mesylate by sodium azide.
    • Synthesis of phosphine-FLAG®, a detection reagent for metabolic labeling of glycans.
    • Synthesis of per-O-acetylated 6-azidofucose, a per-O-acetylated azido sugar.
    Solvent for many hydrophobic organic compounds.

    Packaging

    18, 200 L in Pure-Pac™ 1
    1, 6×1, 2, 4×2 L in Sure/Seal™
    100, 12×100 mL in Sure/Seal™

    SAFETY INFORMATION

    Pictograms

    GHS02,GHS07,GHS08

    Signal Word

    Danger

    Hazard Statements

    H226 - H312 + H332 - H319 - H360D

    Precautionary Statements

    P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313

    Hazard Classifications

    Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

    Storage Class Code

    3 - Flammable liquids

    WGK

    WGK 2

    Flash Point(F)

    135.5 °F - closed cup

    Flash Point(C)

    57.5 °C - closed cup

    Personal Protective Equipment

    dust mask type N95 (US),Eyeshields,Gloves