N,N-Dimethylacetamide for headspace gas chromatography SupraSolv, 1L

SKU:
1003991000
  • $407.00

    • Description

    N,N-Dimethylacetamide

    for headspace gas chromatography SupraSolv®

    Synonym(s):
    N,N-Dimethylacetamide, Acetic acid dimethylamide, Acetyldimethylamine, DMAC, DMA, DMA
    Linear Formula:
    CH3CON(CH3)2
    CAS Number:
    127-19-5
    Molecular Weight:
    87.12
    MDL number:
    MFCD00008686
    EC Index Number:
    204-826-4

    PROPERTIES

    vapor pressure

    1.76 hPa ( 20 °C)

    Quality Level

    100

    product line

    SupraSolv®

    Assay

    ≥99.8% (GC)

    form

    liquid

    autoignition temp.

    400 °C

    potency

    5830 mg/kg LD50, oral (Rat)

    expl. lim.

    1.7-11.5 % (v/v)

    technique(s)

    GC-HS: suitable

    pH

    4 (20 °C, 200 g/L in H2O)

    bp

    165-166 °C/1013 hPa

    mp

    -20 °C

    transition temp

    flash point 64 °C

    solubility

    soluble >1000 g/L

    density

    0.94 g/cm3 at 20 °C

    storage temp.

    2-30°C

    InChI

    1S/C4H9NO/c1-4(6)5(2)3/h1-3H3

    InChI key

    FXHOOIRPVKKKFG-UHFFFAOYSA-N

    DESCRIPTION

    General description

    SupraSolv® high-purity solvents for headspace gas chromatography (HS-GC) are developed particularly for the analysis of residual solvents (RS) in drug substances, excipients and drug products according to ICH (International Council for Harmonizaton of Technical Requirements for Registration of Pharmaceuticals for Human Use) Guideline Q3C»Impurities: Guideline for Residual Solvents«, European Pharmacopeia (Ph. Eur. Chapter 2.4.24) and United States Pharmacopeia (USP Chapter 467).

    Application

    Suitable as a solvent for analysis of residual solvents of ICH classes 1, 2 and 3 according to Ph. Eur. and USP:

    • Every residual solvent of class 1 acc. ICH ≤ 1 µg/g
    • Every residual solvent of class 2 acc. ICH ≤ 10 µg/g
    • Every residual solvent of class 3 acc. ICH ≤ 50 µg/g

    Features and Benefits

    • high application reliability due to the application test performed on every batch produced
    • application-oriented quality due to specified concentrations of residual solvents as defined by ICH

    Legal Information

    SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

    SAFETY INFORMATION

    Signal Word

    Danger

    Hazard Statements

    H312 + H332 - H319 - H360D

    Precautionary Statements

    P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313

    Hazard Classifications

    Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B

    Storage Class Code

    6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    WGK

    WGK 2

    Flash Point(F)

    147.2 °F - closed cup

    Flash Point(C)

    64 °C - closed cup