Description
N,N-Dimethylacetamide
for headspace gas chromatography SupraSolv®
Synonym(s):
N,N-Dimethylacetamide, Acetic acid dimethylamide, Acetyldimethylamine, DMAC, DMA, DMA
Linear Formula:
CH3CON(CH3)2
CAS Number:
127-19-5
Molecular Weight:
87.12
MDL number:
MFCD00008686
EC Index Number:
204-826-4
PROPERTIES
vapor pressure
1.76 hPa ( 20 °C)
Quality Level
100
product line
SupraSolv®
Assay
≥99.8% (GC)
form
liquid
autoignition temp.
400 °C
potency
5830 mg/kg LD50, oral (Rat)
expl. lim.
1.7-11.5 % (v/v)
technique(s)
GC-HS: suitable
pH
4 (20 °C, 200 g/L in H2O)
bp
165-166 °C/1013 hPa
mp
-20 °C
transition temp
flash point 64 °C
solubility
soluble >1000 g/L
density
0.94 g/cm3 at 20 °C
storage temp.
2-30°C
InChI
1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
InChI key
FXHOOIRPVKKKFG-UHFFFAOYSA-N
DESCRIPTION
General description
SupraSolv® high-purity solvents for headspace gas chromatography (HS-GC) are developed particularly for the analysis of residual solvents (RS) in drug substances, excipients and drug products according to ICH (International Council for Harmonizaton of Technical Requirements for Registration of Pharmaceuticals for Human Use) Guideline Q3C»Impurities: Guideline for Residual Solvents«, European Pharmacopeia (Ph. Eur. Chapter 2.4.24) and United States Pharmacopeia (USP Chapter 467).
Application
Suitable as a solvent for analysis of residual solvents of ICH classes 1, 2 and 3 according to Ph. Eur. and USP:
- Every residual solvent of class 1 acc. ICH ≤ 1 µg/g
- Every residual solvent of class 2 acc. ICH ≤ 10 µg/g
- Every residual solvent of class 3 acc. ICH ≤ 50 µg/g
Features and Benefits
- high application reliability due to the application test performed on every batch produced
- application-oriented quality due to specified concentrations of residual solvents as defined by ICH
Legal Information
SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
Signal Word
Danger
Hazard Statements
H312 + H332 - H319 - H360D
Precautionary Statements
P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B
Storage Class Code
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point(F)
147.2 °F - closed cup
Flash Point(C)
64 °C - closed cup