Muscimol, 5MG

The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABA_A and GABA_C and a G protein-coupled receptor, GABA_B. Muscimol is a full GABA_A agonist and partial GABA_C agonist. It binds GABA_A on both high- and low-affinity sites (K_d = 10 and 270 nM, respectively), stimulating chloride efflux with an EC₅₀ value of 200 nM.¹ Benzodiazepines enhance the effects of muscimol via GABA_A without altering its binding.^1,2 Muscimol activates GABA_C receptors with an EC₅₀ value of 1.3 μM.³ It also acts as an inhibitor of GABA_A uptake and a substrate for the GABA-metabolizing enzyme GABA transaminase.⁴ Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs in vivo.^5,6

WARNING This product is not for human or veterinary use.