LY 320135, (HPLC), 5MG

SKU:
L5295-5MG
  • $98.40

    • Description

    LY 320135 ≥98% (HPLC), 5MG

    Synonym(s):
    4-[6-Methoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl]benzonitrile, [6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone, LY320135
    Empirical Formula (Hill Notation):
    C24H17NO4
    CAS Number:
    176977-56-3
    Molecular Weight:
    383.40
    MDL number:
    MFCD00945878
    PubChem Substance ID:
    329817622
    NACRES:
    NA.77

    Quality Level

    100

    assay

    ≥98% (HPLC)

    form

    powder

    color

    orange

    solubility

    DMSO: ≥10 mg/mL

    originator

    Eli Lilly

    storage temp.

    2-8°C

    SMILES string

    COc1ccc(cc1)-c2oc3cc(OC)ccc3c2C(=O)c4ccc(cc4)C#N

    InChI

    1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3

    InChI key

    RYNSGDFWBJWWSZ-UHFFFAOYSA-N

    Packaging

    5, 25 mg in glass bottle

    Biochem/physiol Actions

    LY320135 is a potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM)

    Features and Benefits

    This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
    This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. 

    Pictograms

    GHS06

    Signal Word

    Danger

    Hazard Statements

    H301

    Precautionary Statements

    P301 + P310

    RIDADR

    UN 2811 6.1 / PGIII

    WGK Germany

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable