Kavain, 10MG

SKU:
CAY-26524-10MG
  • $32.00

    • Description

    Kavain, 10MG

    Product Description

    Kavain is a kavalactone and the major constituent of the pepper plant kava (P. methysticum) and has diverse biological activities.1,2,3,4 It is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively, in Xenopus oocytes expressing human receptors.1 Kavain reduces growth of WPMY-1 prostate cancer cells (IC50 = 5.2 µg/ml).2 It reduces LPS-induced TNF-α production in primary murine macrophages in a concentration-dependent manner.3 In vivo, kavain (1 mg/animal) reduces hind paw swelling and TNF-α production in wild-type, but not Erk-/-, mice in a mouse model of collagen-induced arthritis. Kavain also reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg).4

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    (6R)-5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one
    CAS Number
    500-64-1
    Synonyms
    • Kawain
    • NSC 112162
    Molecular Formula
    C14H14O3
    Formula Weight
    230.3
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • DMF: 25 mg/ml
    • DMSO: 25 mg/ml
    • Ethanol: 5 mg/ml
    λmax
    210, 245 nm
    SMILES
    O=C1O[C@@H](/C=C/C2=CC=CC=C2)CC(OC)=C1
    InChi Code
    InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+/t12-/m0/s1
    InChi Key
    XEAQIWGXBXCYFX-GUOLPTJISA-N
    Origin
    Synthetic
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ.