Ibuprofen, (GC), powder, COX inhibitor, 1G

SKU:
I4883-1G
  • $70.80

    • Description

    Ibuprofen, 1G

    ≥98% (GC), powder, COX inhibitor

    Synonym(s):

    2-(4-Isobutylphenyl)propanoic acid, Brufen, Motrin, Rebugen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

    About This Item

    Empirical Formula (Hill Notation):
    C13H18O2
    CAS Number:
    15687-27-1
    Molecular Weight:
    206.28
    EC Number:
    239-784-6
    MDL number:
    MFCD00010393
    UNSPSC Code:
    12352200
    PubChem Substance ID:
    24277715
    NACRES:
    NA.77

    Properties

    product name

    Ibuprofen, ≥98% (GC)

    biological source

    synthetic (organic)

    Quality Level

    100

    assay

    ≥98% (GC)

    form

    powder

    mp

    77-78 °C

    solubility

    ethanol: 50 mg/mL, clear, colorless to faintly yellow

    SMILES string

    CC(C)Cc1ccc(cc1)C(C)C(O)=O

    InChI

    1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

    InChI key

    HEFNNWSXXWATRW-UHFFFAOYSA-N

    Gene Information

    human ... ALB(213) , ALOX5(240) , CYP1A2(1544) , CYP2C9(1559) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)
    mouse ... Alox5(11689)
    rat ... Alox5(25290) , Ptgs1(24693)

    General description

    Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.[1]

    Application

    Ibuprofen has been used:
    • to study its vascular and pulmonary effects on neonatal lung development[2]
    • to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines[3]
    • in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties[4]

    Biochem/physiol Actions

    Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.