gamma-Aminobutyric acid (10g)

SKU:
A2129-10G
  • $17.70

    • Description

    γ-Aminobutyric acid ≥99%

    Synonym: 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid, gamma-Aminobutyric acid

    • CAS Number 56-12-2

       

    • Linear Formula NH2(CH2)3COOH

       

    • Molecular Weight 103.12

       

    •  Beilstein/REAXYS Number 906818

       

    •  EC Number 200-258-6

       

    •  MDL number MFCD00008226

       

    •  PubChem Substance ID 24278167

       

    •  NACRES NA.32

    Properties

    Related Categories Agonists, Amino Acid, Amino acids, Biochemicals and Reagents, Cell Biology,
    Cell Signaling and Neuroscience, Functional Foods, GABA and Glycine Receptor Modulators, GABAergic, GABAergics, 
    GABAergics - GABA-B Agonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Ginkgo biloba, Humulus lupulus (Hops), 
    Hypericum perforatum (St John′s wort), Ion Channels, Ligand-Gated Ion Channels, Membrane Protein Biology Tools, Metabolic Pathways, 
    Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Neuroscience, Neurotransmission, Neurotransmission (Obesity), 
    Neurotransmitters, Nutrition Research, Obesity Research, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), Proteins and Derivatives, 
    Zingiber officinale (Ginger)
    Quality Level 200
    assay ≥99%
    mp 195 °C (dec.) (lit.)
    SMILES string NCCCC(O)=O
    InChI 1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
    InChI key BTCSSZJGUNDROE-UHFFFAOYSA-N
    Gene Information

    human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), 

    GABRB1(2560), GABRB2(2561), GABRB3(2562), SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
    rat ... Gabbr1(81657), Gabra1(29705), Gabra2(29706), Gabrb2(25451), Gabrg2(29709), Slc6a1(79212), Slc6a12(50676)

    Application

    γ-Aminobutyric acid (GABA) has been used:
    • in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining[1]
    • in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)[2]
    • in the intraintestinal application of GABA in order to increase intraluminal fluid secretion[3]

    Biochem/physiol Actions

    GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and also functions as a neuromodulator in some peripheral tissues. It binds to GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in lowering of excitability of the cell.[4]
    GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anaesthetics. GABA can also influence heart rate and blood pressure.[5]

    Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance.

    Features and Benefits

    This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

    Legal Information

    LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

    Safety Information

    Personal Protective Equipment 
    dust mask type N95 (US), Eyeshields, Gloves
    RIDADR 
    NONH for all modes of transport
    WGK Germany 
    2
    RTECS 
    ES6300000