Duloxetine-d3 (hydrochloride), 1MG

SKU:
CAY-25229-1MG
  • $194.00

    • Description

    Duloxetine-d3 (hydrochloride), 1MG

    Item No. 25229

    Technical Information
    Formal Name
    N-(methyl-d3)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, monohydrochloride
    CAS Number
    1188266-11-6
    Synonyms
    • LY248686-d3
    Molecular Formula
    C18H16D3NOS • HCl
    Formula Weight
    336.9
    Purity
    ≥99% deuterated forms (d1-d3)
    Formulation
    A solid
    Solubility
    • Water: 5 mg/ml
    SMILES
    [2H]C([2H])([2H])NCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
    InChi Code
    InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/i1D3;
    InChi Key
    BFFSMCNJSOPUAY-NIIDSAIPSA-N
    Shipping & Storage Information
    Storage
    4°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Duloxetine-d3 is intended for use as an internal standard for the quantification of duloxetine (Item No. 14317) by GC- or LC-MS. (S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes).1 It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively).2 It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg.3 Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.

    WARNING This product is not for human or veterinary use.