Difenoconazole-d₆ (hydrochloride)

Difenoconazole-d₆ is intended for use as an internal standard for the quantification of difenoconazole (Item No. 24053) by GC- or LC-MS. Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.^1,2 It inhibits the growth of F. graminearum isolates in vitro (EC₅₀s = 1.69-19.6 mg/L for mycelial growth).² It also inhibits growth of A. sonali, F. fulva, B. cinerea, and R. solani (EC₅₀s = 0.131, 0.069, 0.297, and 0.252 mg/L, respectively).³ Difenoconazole reduces germtube growth of A. caricae, the mold responsible for black spot in papaya plants (EC₅₀ = 2 ppm).⁴ It exhibits acute aquatic toxicity, reducing growth of S. obliquus algae (EC₅₀ = 1.338 μg/ml) and decreasing survival of D. magna (LD₅₀ = 0.298 μg/ml).³ Difenoconazole is also lethal to zebrafish (D. rerio) embryos, larvae, and adults (LC₅₀s = 2.34, 1.17, and 1.45 mg/L, respectively).⁵ At sub-LC₅₀ concentrations, difenoconazole induces pericardial and yolk sac edema in zebrafish embryos, body blackening and slowed heart rate in larvae, and decreased body weight and length in adults.

WARNING This product is not for human or veterinary use.

This product is sold exclusively for research and analytical uses. It is formulated and packaged for use in controlled laboratory settings. Bulk sizes are not available for purchase.