Curcumin, (curcuminoid content), (Curcumin), 500MG

SKU:
C7727-500MG
  • $197.00

    • Description

    Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin), 500MG

     

    ≥94% (curcuminoid content), ≥80% (Curcumin)

    Synonym(s):
    Diferulylmethane, (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Natural Yellow 3
    Linear Formula:
    [HOC6H3(OCH3)CH=CHCO]2CH2
    CAS Number:
    458-37-7
    Molecular Weight:
    368.38
    Colour Index Number:
    75300
    Beilstein:
    2306965
    EC Number:
    207-280-5
    MDL number:
    MFCD00008365
    PubChem Substance ID:
    24892983
    NACRES:
    NA.47

    PROPERTIES

    Quality Level

    200

    vapor density

    13 (vs air)

    assay

    ≥80% (Curcumin)
    ≥94% (curcuminoid content)

    form

    powder

    mp

    175 °C

    solubility

    ethanol: 1 mg/mL
    DMSO: >11 mg/mL
    0.5 M NaOH: soluble (then immediately diluted in PBS)

    storage temp.

    −20°C

    SMILES string

    COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

    InChI

    1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

    InChI key

    VFLDPWHFBUODDF-FCXRPNKRSA-N

    Gene Information

    human ... APP(351) , CYP1A2(1544)

    General description

    Curcumin is a yellow colored polyphenol obtained from the rhizome of Curcuma longa L. It is also known as diferuloyl methane, a symmetric molecule with a seven carbon linker connecting two o-methoxy phenolic groups containing aromatic rings. Curcumin is synthesized by Pabon′s reaction using vanillin and acetyl acetone in the presence of boric oxide. It constitutes an important part of various diets and herbal medicines, especially in the Asian continent for its various salubrious effects on human health.

    Application

    Curcumin has been used:
    • to study its in vitro effect on the inflammation and expression of tumour factor in patients with chronic kidney diseases
    • to determine its influence when used in combination with high frequency ultrasound on human cervical carcinoma cells
    • to study the possibility of using magnetic purification of curcumin from Curcuma longa by surface active maghemite nanoparticles (SAMNs)
    • to examine its effect on the amyloid-β peptide levels along with the maturation of amyloid-β precursor proteins in various cell lines and primary cortical neurons in mouse
    • as a supplement to evaluate its anti-carcinogenic and anti-apoptotic effect on cancer cells and cardiomyocytes
    • to test its anti-inflammatory effect in human promyelocytic leukemia cell line, the HL-60

    Packaging

    500 mg in poly bottle

    Biochem/physiol Actions

    A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
    Curcumin is postulated to have anti-depressant, anti-stress and neuroprotective effects on humans and other animals. Additionally, it also shows anti-fungal, antiviral, anti-microbial, chemosensitizing, radiosensitizing, and wound healing activities.

    SAFETY INFORMATION

    Storage Class Code

    13 - Non Combustible Solids

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable