Cotrimoxazole, Ready Made Solution, 100mg/mL in DMSO

SKU:
A2487-1ML
  • $619.00

    • Description

    Cotrimoxazole, Ready Made Solution

    100 mg/mL in DMSO

    Synonym(s):
    Trimethoprim-Sulfamethoxazole, TMP-SMX
    Empirical Formula (Hill Notation):
    C14H18N4O3 · 5 C10H11N3O3S
    CAS Number:
    8064-90-2
    Molecular Weight:
    1556.71
    NACRES:
    NA.85

    PROPERTIES

    form

    liquid

    Quality Level

    200

    concentration

    100 mg/mL in DMSO

    color

    colorless to faint yellow

    antibiotic activity spectrum

    Gram-negative bacteria
    Gram-positive bacteria
    fungi
    parasites

    mode of action

    DNA synthesis | interferes

    shipped in

    dry ice

    storage temp.

    −20°C

    InChI

    1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

    InChI key

    WZRJTRPJURQBRM-UHFFFAOYSA-N

    DESCRIPTION

    Application

    Cotrimoxazole has been used as an antimicrobial agent.[1][2]

    Biochem/physiol Actions

    Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

    Packaging

    1ml

    Preparation Note

    prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

    Other Notes

    Keep container tightly closed in a dry and well-ventilated place.

    SAFETY INFORMATION

    signalword

    Warning

    hcodes

    H361fd - H412

    pcodes

    P202 - P273 - P280 - P308 + P313 - P405 - P501

    Hazard Classifications

    Aquatic Chronic 3 - Repr. 2

    Storage Class

    12 - Non Combustible Liquids

    wgk_germany

    WGK 2

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable