Citric acid, 1G, Anhydrous, Pharmaceutical Secondary Standard; Certified Reference Material

SKU:
PHR1071-1G
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    • Description

    Citric acid, 1G, Anhydrous, Pharmaceutical Secondary Standard; Certified Reference Material

    Synonym(s):
    Citric acid
    Linear Formula:
    HOC(COOH)(CH2COOH)2
    CAS Number:
    77-92-9
    Molecular Weight:
    192.12
    Beilstein:
    782061
    EC Number:
    201-069-1
    MDL number:
    MFCD00011669
    eCl@ss:
    39021801
    PubChem Substance ID:
    329823094
    NACRES:
    NA.24

    PROPERTIES

    Quality Level

    300

    grade

    certified reference material
    pharmaceutical secondary standard

    Agency

    traceable to Ph. Eur. A1202000
    traceable to USP 1134368

    CofA

    current certificate can be downloaded

    expl. lim.

    8 %, 65 °F

    technique(s)

    HPLC: suitable
    gas chromatography (GC): suitable

    pKa 

    (1) 3.13, (2) 4.76, (3) 6.4

    mp

    153-159 °C (lit.)

    application(s)

    pharmaceutical (small molecule)

    format

    neat

    storage temp.

    2-30°C

    SMILES string

    OC(=O)CC(O)(CC(O)=O)C(O)=O

    InChI

    1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

    InChI key

    KRKNYBCHXYNGOX-UHFFFAOYSA-N

    DESCRIPTION

    General description

    Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
    Citric acid is a common ingredient in pharmaceutical formulations. It finds use in antacids and dentrifices because of the effervescent effect it generates upon combination with carbonates or bicarbonates. Citric acid may also be used as a buffering agent and it assists in the dispersion of suspensions in order to ensure the stability of the active ingredients and enhance the efficacy of antioxidants.

    Application

    Anhydrous citric acid may be used as a reference standard in determining the concentration of citric acid present in biological fluids using spectrophotometric method.
    These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
    Citric acid, Anhydrous may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and milk samples by various chromatography techniques.

    Analysis Note

    These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

    Other Notes

    This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

    SAFETY INFORMATION

    Signal Word

    Warning

    Hazard Statements

    H319 - H335

    Precautionary Statements

    P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

    Hazard Classifications

    Eye Irrit. 2 - STOT SE 3

    Target Organs

    Respiratory system

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 1

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable