Chlorpromazine-d6 (hydrochloride)

SKU:
CAY-25636-500UG
  • $106.00

    • Description

    Chlorpromazine-d6 (hydrochloride)

    Chlorpromazine-d6 (CPZ-d6) is intended for use as an internal standard for the quantification of CPZ (Item No. 16129) by GC- or LC-MS. CPZ is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM).1,2 It is also an antagonist of histamine H1, α1A-, α2B-, and α2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively).3 CPZ (10 mg/kg per day) increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats.4 CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis induced by cisplatin (Item No. 13119) in dogs.5

    WARNING This product is not for human or veterinary use

    Technical Information
    Formal Name
    2-chloro-N,N-di(methyl-d3)-10H-phenothiazine-10-propanamine, monohydrochloride
    CAS Number
    1228182-46-4
    Synonyms
    • CPZ-d6
    Molecular Formula
    C17H13ClD6N2S • HCl
    Formula Weight
    361.4
    Purity
    ≥99% deuterated forms (d1-d6)
    Formulation(Request formulation change)
    A solid
    Solubility
    • DMF: 30 mg/ml
    • DMSO: 30 mg/ml
    • Ethanol: 30 mg/ml
    • PBS (pH 7.2): 10 mg/ml
    SMILES
    ClC1=CC=C(SC(C=CC=C2)=C2N3CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C3=C1.Cl
    InChi Code
    InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H/i1D3,2D3;
    InChi Key
    FBSMERQALIEGJT-TXHXQZCNSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years