• Manufactured under ISO/IEC17025:2005 and ISO Guide 34:2009 specifications
• This is a Certified Reference Material (CRM) intended for use as a quantitative analytical reference standard
• Has been formulated as an exempt preparation which meets criteria established by the US DEA
• Possession of a DEA Controlled Substance registration is not necessary nor is a DEA 222 form required to purchase this product

• CBD

Cannabidiol is an active phytocannabinoid identified in Cannabis (composes ~40% of the plant's extract). Unlike Δ⁹-THC (Item No. CAY 12068), cannabidiol is considered to be non-psychoactive.¹ Cannabidiol has a very low affinity for CB₁ and CB₂ receptors but acts as an indirect antagonist and is thought to potentiate the effects of Δ⁹-THC.² Cannabidiol is reported to act as an CB₂ receptor inverse agonist, GPR55 antagonist, and a 5-HT_1A receptor agonist.^2,3,4,5 It can allosterically modulate μ and δ-opioid receptors as well as agonize PPARγ receptors and stimulate intracellular calcium release.^6,7

Cayman Chemical products containing Certified Reference Material (CRM) in the name are highly qualified materials manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 international guidelines for reference materials. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability to SI units of measure. Cayman’s CRMs are tested for Homogeneity and Stability and are provided with a certificate stating the CRM property value(s) along with the combined uncertainty of the property value(s). These materials are intended for quantitative applications where quantitative accuracy and uncertainty are critical. Cayman Chemical is committed to providing quality products to its customers as evidenced by its accreditation to the ISO/IEC 17025 and ISO Guide 34 standards.