Description
(±)-Camphene, 1G
Product Description
(±)-Camphene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has diverse biological activities, including antiproliferative, pro-apoptotic, hypolipidemic, and insecticidal properties.1,2,3,4,5 It inhibits proliferation of B16/F10-Nex2 mouse melanoma, as well as human A2058 melanoma, HL-60 leukemia, U87MG glioblastoma, and SK-BR-3 breast cancer cells (IC50s = 71.2, 35.2, 27, 55.4, and 34.7 μg/ml, respectively).2 (±)-Camphene (70 μg/ml) increases caspase-3 activity and induces apoptosis and endoplasmic reticulum stress in B16/F10-Nex2 cells. It lowers plasma levels of total cholesterol, LDL cholesterol, and triglycerides (TGs) in a Triton WR-1339-induced rat model of hyperlipidemia when administered at a dose of 1.5 μg/g.3 Dietary administration of (±)-camphene (0.2%) also inhibits hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced obesity.4 It also has larvicidal activity against third instar H. armigera larvae (LC50 = 10.64 μg/ml) and ovicidal activity against H. armigera eggs (EC50 = 35.39 μg/ml).5 Formulations containing (±)-camphene have been used as perfume and food additives.
WARNING This product is not for human or veterinary use.
Technical Information
- DL-Camphene
- NSC 4165
- Chloroform: Soluble
- Ethanol: slightly soluble