Caffeine, Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1009-1G
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    • Description

    Caffeine, Pharmaceutical Secondary Standard; Certified Reference Material

    Synonym(s):
    1,3,7-Trimethylxanthine
    Empirical Formula (Hill Notation):
    C8H10N4O2
    CAS Number:
    58-08-2
    Molecular Weight:
    194.19
    Beilstein:
    17705
    MDL number:
    MFCD00005758
    PubChem Substance ID:
    329823040
    NACRES:
    NA.24

    grade

    certified reference material
    pharmaceutical secondary standard

    Quality Level

    300

    Agency

    traceable to BP 766
    traceable to Ph. Eur. C0100000
    traceable to USP 1085003

    CofA

    current certificate can be downloaded

    technique(s)

    HPLC: suitable
    gas chromatography (GC): suitable

    mp

    234-236.5 °C (lit.)

    application(s)

    pharmaceutical (small molecule)

    format

    neat

    storage temp.

    2-30°C

    SMILES string

    CN1C(=O)N(C)c2ncn(C)c2C1=O

    InChI

    1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

    InChI key

    RYYVLZVUVIJVGH-UHFFFAOYSA-N

    Gene Information

    human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

    Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.

    Application

    Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.
    These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

    Biochem/physiol Actions

    A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

    Analysis Note

    These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

    Other Notes

    This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

    Footnote

    To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

    SAFETY INFORMATION

    Pictograms

    GHS07

    Signal Word

    Warning

    Hazard Statements

    H302

    Precautionary Statements

    P264 - P270 - P301 + P312 - P501

    Hazard Classifications

    Acute Tox. 4 Oral

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 1