Caffeine Melting Point Standard, Pharmaceutical Secondary Standard; Certified Reference Material

SKU:
PHR1095-1G
  • $87.80

    • Description

    Caffeine Melting Point Standard, Pharmaceutical Secondary Standard; Certified Reference Material

    Synonym(s):
    Caffeine, 1,3,7-Trimethylxanthine
    Empirical Formula (Hill Notation):
    C8H10N4O2
    CAS Number:
    58-08-2
    Molecular Weight:
    194.19
    Beilstein:
    17705
    EC Number:
    200-362-1
    MDL number:
    MFCD00005758
    PubChem Substance ID:
    329823117
    NACRES:
    NA.24

    Quality Level

    300

    grade

    certified reference material
    pharmaceutical secondary standard

    Agency

    traceable to USP 1086006

    CofA

    current certificate can be downloaded

    technique(s)

    HPLC: suitable
    gas chromatography (GC): suitable

    mp

    ~Approximately 237 °C
    234-236.5 °C (lit.)

    application(s)

    pharmaceutical (small molecule)

    format

    neat

    storage temp.

    2-30°C

    SMILES string

    CN1C(=O)N(C)c2ncn(C)c2C1=O

    InChI

    1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

    InChI key

    RYYVLZVUVIJVGH-UHFFFAOYSA-N

    Gene Information

    human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

    Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
    Caffeine is mainly used as a diuretic and as a stimulant to central nervous system, heart rate, and respiration.

    Application

    These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
    Caffeine may be used as a reference standard for the determination of the analyte in pharmaceutical formulations by high-performance liquid chromatography and spectrophotometry.

    Biochem/physiol Actions

    A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

    Analysis Note

    These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

    Other Notes

    This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

    Pictograms

    GHS07

    Signal Word

    Warning

    Hazard Statements

    H302

    Precautionary Statements

    P264 - P270 - P301 + P312 - P501

    Hazard Classifications

    Acute Tox. 4 Oral

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 1