Caffeine anhydrous, FCC, FG, Sample, 10G

SKU:
W222402-SAMPLE-K
  • $54.60

    • Description

    Caffeine anhydrous, 99%, FCC, FG, Sample

    Synonym: 1,3,7-Trimethylxanthine

    • CAS Number 58-08-2

       

    • Empirical Formula (Hill Notation) C8H10N4O2

       

    • Molecular Weight 194.19

       

    •  FEMA Number 2224

       

    •  Beilstein/REAXYS Number 17705

       

    •  EC Number 200-362-1

       

    •  Council of Europe no. 11741

       

    •  MDL number MFCD00005758

       

    •  PubChem Substance ID 24900939

       

    •  Flavis number 16.016

       

    •  NACRES NA.21

    Properties

    Related Categories A - D, A-D, Alphabetical Listings, C-D, Certified Food Grade Products,
    Flavors and Fragrances, Halal Certified Products, Kosher Certified Products
    Less...
    Quality Level 400
    biological source synthetic
    grade FG
     - Halal
     -  Kosher
     -  anhydrous
    reg. compliance EU Regulation 1334/2008 & 178/2002
     -  FCC
     -  FDA 21 CFR 182.1180
    assay 99%
    form powder
    mp 234-236.5 °C (lit.)
    solubility H2O: soluble 18.7 g/L at 16 °C
    Documentation see Safety & Documentation for available documents
    Organoleptic odorless
    food allergen no known allergens
    SMILES string CN1C(=O)N(C)c2ncn(C)c2C1=O
    InChI 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
    InChI key RYYVLZVUVIJVGH-UHFFFAOYSA-N
    Gene Information human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142)
    mouse ... Adora2b(11541)
    rat ... Adora1(29290), Adora2a(25369)

    General description

    Caffeine is an addictive psychoactive compound, consumed mostly in the form of brewed coffee, instant coffee, tea and caffeinated soft drinks.[3] Caffeine is reported to be an allergen and causes anaphylaxis.[6] It is added to common analgesics such as paracetamol, ibuprofen and aspirin for enhancing their analgesic efficacy.[7] It is a plant-derived drug and has been detected in low doses in the floral nectar and pollen of Citrus.[1] Determination of caffeine in beverages by square-wave voltammetry using Nafion-ruthenium oxide pyrochlore chemically modified electrode has been reported.[2] Caffeine acts as an antagonist of adenosine A1 receptors (A1R) and A2AR at non-toxic doses.[4] Chronic consumption of caffeine is reported to prevent the memory impairment in type 2 diabetic mice.[4]

    Application

    Caffeine (1,3,7-Trimethylxanthine) has been used in a study to determine the benefits of co-ingestion of carbohydrate and caffeine on rugby performance.[8]

    Caffeine is the suitable reagent used to investigate effect of its exposure during embryogenesis.[5]

    Packaging

    1 kg in poly bottle

    10, 25 kg in fiber drum

    Biochem/physiol Actions

    A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

    Other Notes

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    Safety Information

    Symbol 
    GHS07
    Signal word 
    Warning
    Hazard statements 
    H302
    Precautionary statements 
    P301 + P312 + P330
    Personal Protective Equipment 
    dust mask type N95 (US), Eyeshields, Faceshields, Gloves
    RIDADR 
    NONH for all modes of transport
    WGK Germany 
    WGK 1
    RTECS 
    EV6475000
    Flash Point(F) 
    Not applicable
    Flash Point(C) 
    Not applicable