Benfotiamine, 1G

SKU:
CAY-22192-1G
  • $84.00

    • Description

    Benfotiamine, 1G
    Technical Information
    Formal Name
    benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester
    CAS Number
    22457-89-2
    Synonyms
    • Benzoylthiamine monophosphate
    Molecular Formula
    C19H23N4O6PS
    Formula Weight
    466.5
    Purity
    ≥98%
    A crystalline solid
    Solubility
    • 0.1m NH4OH: 1 mg/ml
    • DMSO: slightly soluble
    λmax
    243 nm
    SMILES
    C/C(N(CC1=CN=C(C)N=C1N)C=O)=C(SC(C2=CC=CC=C2)=O)\CCOP(O)(O)=O
    InChi Code
    InChI=1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13-
    InChi Key
    BTNNPSLJPBRMLZ-LGMDPLHJSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 2 years
    Product Description

    Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine). In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions. In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes. Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication. Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer's disease. It also improves spatial memory performance in the Morris water maze.

    WARNING This product is not for human or veterinary use.