Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.^1,2,3,4,5 It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8⁺ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.² It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.³ Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).⁴ It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.⁵

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