Baclofen-d4, 1mg, analytical standard, neat

SKU:
CAY-27811-1mg
  • $667.50

    • Description

    (±)-Baclofen-d4

    Item No. 27811

    Technical Information
    Formal Name
    4-amino-3-(4-chlorophenyl-2,3,5,6-d4)butanoic acid
    CAS Number
    1189938-30-4
    Molecular Formula
    C10H8ClD4NO2
    Formula Weight
    217.7
    Purity
    ≥99% deuterated forms (d1-d4)
    Formulation(Request formulation change)
    A solid
    Solubility(Learn about Variance in Solubility)
    • Water: soluble
    SMILES
    ClC1=C([2H])C([2H])=C(C(CN)CC(O)=O)C([2H])=C1[2H]
    InChi Code
    InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/i1D,2D,3D,4D
    InChi Key
    KPYSYYIEGFHWSV-RHQRLBAQSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    (±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen (Item No. 18600) by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.

    WARNING This product is not for human or veterinary use.