Avermectin B1a, 1mg

SKU:
CAY-22000-1MG

    • Description

    Avermectin B1a, 1mg

    Technical Information
    Formal Name
    5-O-demethyl-avermectin A1a
    CAS Number
    65195-55-3
    Synonyms
    • Abamectin B1a
    • Antibiotic C 076B1a
    • L-676,863
    Molecular Formula
    C48H72O14
    Formula Weight
    873.1
    Purity
    ≥95%
    Formulation
    A solid
    Solubility
    • Chloroform: Slightly soluble
    • Methanol: Slightly soluble
    SMILES
    C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(C=C[C@H](C)[C@]([C@@H](C)CC)([H])O7)O6
    InChi Code
    InChI=1S/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
    InChi Key
    RRZXIRBKKLTSOM-XPNPUAGNSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 6 months
    Product Description

    Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor.1,2,3 Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel.3 Avermectin B1a inhibits binding of the glycine receptor antagonist strychnine to membranes and the solubilized receptor from rat spinal cord (Kis = 1.3 and 3.6 µM, respectively).4 Formulations containing avermectin B1a (>80%) and avermectin B1b (~20%; Item No. 17453) are used in insecticides and veterinary anthelmintic formulas as abamectin (Item No. 19201).5,6

    WARNING This product is not for human or veterinary use.

    This product is sold exclusively for research and analytical uses. It is formulated and packaged for use in controlled laboratory settings. Bulk sizes are not available for purchase.