Aripiprazole-d₈ is intended for use as an internal standard for the quantification of aripiprazole (Item No. 19989) by GC- or LC-MS. Aripiprazole is an atypical antipsychotic.¹ It is a partial agonist at dopamine D₂, D_2L, and D₃ receptors (K_is = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT_1A (K_i = 5.6 nM), and an inverse agonist of 5-HT_2B receptors (K_i = 0.36 nM). It is functionally selective at the dopamine D₂ receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg.² Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette’s disorder.

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