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AM630, (HPLC), 5MG

SKU:
SML0327-5MG
  • $158.00

    • Description

    AM630 ≥90% (HPLC), 5MG

    Synonym(s):
    6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone, AM 630, Iodopravadoline
    Empirical Formula (Hill Notation):
    C23H25IN2O3
    CAS Number:
    164178-33-0
    Molecular Weight:
    504.36
    MDL number:
    MFCD01861183
    PubChem Substance ID:
    329825332
    NACRES:
    NA.77

    Quality Level

    100

    assay

    ≥90% (HPLC)

    form

    powder

    storage condition

    desiccated

    color

    white to beige

    solubility

    DMSO: >5 mg/mL

    storage temp.

    2-8°C

    SMILES string

    COc1ccc(cc1)C(=O)c2c(C)n(CCN3CCOCC3)c4cc(I)ccc24

    InChI

    1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3

    InChI key

    JHOTYHDSLIUKCJ-UHFFFAOYSA-N

    Application

    AM630 has been used:
    • as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from Trametes versicolor (TPSP).
    • as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
    • as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.

    Packaging

    5, 25 mg in glass bottle

    Biochem/physiol Actions

    AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).
    AM630 is a selective CB2 cannabinoid antagonist/inverse agonist (Ki = 31.2 nM) with > 150-fold selectivity over CB1 receptors.

    Features and Benefits

    This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. 

    Pictograms

    GHS09

    Signal Word

    Warning

    Hazard Statements

    H410

    Precautionary Statements

    P273 - P501

    RIDADR

    UN 3077 9 / PGIII

    WGK Germany

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable