5a-Androst-16-en-3a-ol, 10MG

SKU:
CAY- 33457-10MG
  • $57.00

    • Description

    5α-Androst-16-en-3α-ol

    Technical Information
    Formal Name
    (3α,5α)-androst-16-en-3-ol
    CAS Number
    1153-51-1
    Synonyms
    • Androstenol
    • E 281
    • NSC 71076
    Molecular Formula
    C19H30O
    Formula Weight
    274.4
    Purity
    ≥95%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • DMF: 20 mg/ml
    • DMSO: 10 mg/ml
    • Ethanol: 30 mg/ml
    SMILES
    C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C=CC4)C
    InChi Code
    InChI=1S/C19H30O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h3,9,13-17,20H,4-8,10-12H2,1-2H3/t13-,14+,15-,16-,17-,18-,19-/m0/s1
    InChi Key
    KRVXMNNRSSQZJP-PHFHYRSDSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years

    5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2 It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM).2 5α-Androst-16-en-3α-ol (0.1-1 µM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors. In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5α-Androst-16-en-3α-ol protects against seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    Technical Support & Resources

    Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.